1. VA Watchdog dot Org - VA NEWS FLASH - 04-12-2007 #3 -- VA RESEARCH FINDS DRUG HELPS PTSD NIGHTMARES -- Veterans taking a nightly dose of prazosin reported significantly improved sleep quality, reduced trauma nightmares, a better overall sense of well being and an improved ability to function.nf041207-3.htm
...- Veterans taking a nightly dose of prazosin reported significantly improved sleep quality, reduced ...- Veterans taking a nightly dose of prazosin reported significantly improved sleep quality, reduced ... 40 veterans compared a nightly dose of prazosin (PRAISE-oh-sin) ... at bedtime. The average dose of prazosin in the trial was 13.3 mg. By comparison, typical prazosin doses for controlling blood pressure or treating .... In this study, veterans taking prazosin reported that they resumed normal dreaming. One dose of prazosin works for 6 to 8 hours. Unlike similar drugs, prazosin does not induce tolerance; people can... http://www.vawatchdog.org/07/nf07/nfAPR07/nf041207-3.htm
...- Comment at bottom of page. Prazosin VA FINDS COMMON BLOOD PRESSURE DRUG RELIEVES NIGHTMARES Nighttime use of Prazosin started at the Seattle VA hospital and ...'ll find more background information on Prazosin here ... http:/ .../sessearch.php?q=prazosin&op=and --- ... it as a long shot. 'Prazosin has changed so, so much in ... Vietnam to Iraq and Afghanistan are taking prazosin for trauma-related nightmares. Its ... across the country. Today, the prazosin initiative is one of Madigan Army Medical ... now deployed in combat zones are taking prazosin, also sold by the trade names... http://www.vawatchdog.org/09/nf09/nfdec09/nf121509-5.htm
... CURBS BRAIN DAMAGE FROM PTSD -- Prazosin, also used as antipsychotic, may ... pressure drug curbs brain damage from PTSD Prazosin, also used as antipsychotic, may ...s disease, depression and schizophrenia. Prazosin, also prescribed as an antipsychotic medication ... and the PVAMC. "We think prazosin protects the brain from being damaged by ....com The study, titled "Prazosin attenuates dexamethasone-induced HSP70 expression in ... forms. To determine the effects of prazosin, OHSU and PVAMC researchers, led ... a marker for neurotoxicity. Pretreatment with prazosin, an alpha-1 receptor antagonist ... stress, so could we give them prazosin ahead of time to protect them from... http://www.vawatchdog.org/07/nf07/nfNOV07/nf110707-7.htm
... are suffering acute symptoms as well as for those who are relatively stable." Prazosin Reduces Trauma Nightmares and Severe Sleep Disturbance in Soldiers Deployed in Iraq Principal Investigators ... environment, and these symptoms are difficult to treat. Prior research has revealed that prazosin improves sleep and daytime function in Vietnam combat veterans with chronic PTSD and is ... the study, 13 active duty soldiers received between 1 mg and 10 mg of prazosin at bedtime. All had experienced life-threatening combat events or other traumatic ... any parameter. The open-label trial results are consistent with placebo-controlled prazosin trials in chronic PTSD in Vietnam veterans and civilians. Because clinical trials are... http://www.vawatchdog.org/09/nf09/nfsep09/nf090209-6.htm
5. VA Watchdog dot Org - VA NEWS FLASH - 12-02-06 #2nf120206-2.htm
..." Neylan said a newer drug that works on norepinephrine receptors, but in a different way, might still succeed where guanfacine has failed. That drug, called prazosin, blocks the alpha-1 receptor in the synapse. "There have been a few trials to show that prazosin does have some promise, and I know the VA is gearing up to do a large multi-site study. It is becoming more popular." In... http://www.vawatchdog.org/nfDEC06/nf120206-2.htm
... people. They range from psychotherapy to medications for depression, anxiety and insomnia. Other more innovative techniques, such as image rehearsal therapy, focus on training the brain to overcome nightmares by practising new dreams during the day. Germain hopes the studies which also compare sleeping brains between people who have used the blood pressure drug Prazosin, which has been proven to help PTSD symptoms will have preliminary findings by the end of this year. It is being funded in part by the United States Defense Department and the U.S. National Institute of Mental Health. ---------------... http://www.vawatchdog.org/10/nf10/nfjan10/nf011210-6.htm
... a traumatic event has blunted production. A two-week dose of steroids "could help normalize that system," said researcher Catherine Johnson. Use of the drugs risperidone and quetiapine, both antipsychotics developed for schizophrenia, in addition to the antidepressants typically given to patients with PTSD. Researchers are also testing the use of prazosin, a blood pressure medication that slows down the sympathetic nervous system, commonly known as the "fight or flight" response to danger. PTSD, according to recently published studies, has afflicted 10 percent to 13 percent of soldiers returning from the conflicts in the Middle East. More than 20 percent of Vietnam veterans... http://www.vawatchdog.org/old newsflashes MAR 06/newsflash03-22-2006-4.htm
8. VA Watchdog dot Org - VA NEWS FLASH - 04-18-2007 #7 -- PTSD NEEDS TO BE RECOGNIZED IN PRIMARY CARE -- While PTSD is widely recognized today, it often remains undiagnosed and undertreated.nf041807-7.htm
... olanzapine, when added to SSRI treatment, achieved a therapeutic response in 4 studies involving veterans and no response in another study. Some studies of monoamine oxidase inhibitor monotherapy and tricyclic antidepressant monotherapy also showed promising effects if the medications were taken for at least 2 months. The combination of adrenergic antagonists and agonists with the antihypertensive prazosin seemed to be effective for some patients as well. Medications to treat specific comorbid conditions may also be warranted, such as buproprion for smoking cessation. Physicians also continue to prescribe benzodiazepines for PTSD, although studies have not found any benefit from benzodiazepine therapy. However, benzodiazepines are not recommended as a principal or sole... http://www.vawatchdog.org/07/nf07/nfAPR07/nf041807-7.htm
9. VA Watchdog dot Org - VA NEWS FLASH - 05-29-2007 #10 -- HAUNTED BY MEMORIES, A RETIRED COMMAND SERGEANT MAJOR SEEKS CHANGE -- At a dusty desert base in Kuwait, Adams went from unit to unit, telling his fellow soldiers that he was not OK and would seek counseling when he returned. He urged others to do the same.nf052907-10.htm
... Washington, D.C., for briefings before flying to Iraq. His luggage included a year's supply of drugs to help him through the year. There was Seroquel, the mood-stabilizing tranquilizer he had been taking ever since the last few months of Mosul combat. There was a new drug, prazosin, a blood-pressure medication that Dr. Raskind has successfully used to help post-traumatic stress patients sleep. At the briefings, Adams learned he would be flying into Balad, a major U.S. base in Iraq that included a hospital. That triggered bad memories. In Mosul, all the... http://www.vawatchdog.org/07/nf07/nfMAY07/nf052907-10.htm
10. VA Watchdog dot Org - VA NEWS FLASH - 06-25-2007 #1 -- CHANGES IN THE VA DISABILITY SYSTEM -- SECOND OF THREE PARTS -- A special series from Veterans' Advocate Jim Strickland.nf062507-1.htm
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